[HTML][HTML] Inhibition of obliterative airway disease development in murine tracheal allografts by matrix metalloproteinase-9 deficiency
FG Fernández, LG Campbell, W Liu, JM Shipley… - American Journal of …, 2005 - Elsevier
This study was designed to define the roles of matrix metalloproteinase (MMP)-2 and MMP-9
inobliterative airway disease (OAD) in heterotopic murine tracheal allografts, considered a
suitable animal model for chronic lung allograft rejection. BALB/c tracheal allografts were
transplanted into MMP-2-deficient (–/–) and MMP-9–/–mice. Also, wild-type recipients were
treated with doxycycline, a nonspecific MMP inhibitor. After 10, 20 and 30 days, allografts
were analyzed for OAD development, intragraft levels of MMP-2 and MMP-9 and the …
inobliterative airway disease (OAD) in heterotopic murine tracheal allografts, considered a
suitable animal model for chronic lung allograft rejection. BALB/c tracheal allografts were
transplanted into MMP-2-deficient (–/–) and MMP-9–/–mice. Also, wild-type recipients were
treated with doxycycline, a nonspecific MMP inhibitor. After 10, 20 and 30 days, allografts
were analyzed for OAD development, intragraft levels of MMP-2 and MMP-9 and the …